@Article{biocell.2022.018471,
AUTHOR = {MARIANO BIZZARRI, PAOLA PONTECORVI},
TITLE = {Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {6},
PAGES = {1357--1362},
URL = {http://www.techscience.com/biocell/v46n6/46704},
ISSN = {1667-5746},
ABSTRACT = {The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex
structure that confers stability to cell shape while serving as sensor of internal/extracellular changes.
Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by
fostering symmetry breakings and transitions across different phenotypic states. Such process induces a wholecoherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These
characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk
between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton can
be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area
of interest in cancer and developmental biology.},
DOI = {10.32604/biocell.2022.018471}
}