@Article{biocell.2022.018530,
AUTHOR = {ZIQIAN WANG, YAQI LI, DONGYANG WANG, YINGQIANG SHEN},
TITLE = {Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {7},
PAGES = {1599--1611},
URL = {http://www.techscience.com/biocell/v46n7/47031},
ISSN = {1667-5746},
ABSTRACT = {Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have
glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation,
Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly,
many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a
number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the
study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic
process of ferroptosis, the role of different organelles, the typical signaling pathways involved in ferroptosis, as well as
natural and synthetic compounds that can induce ferroptosis, aiming to point out new conceptual avenues for
utilizing ferroptosis in future cancer treatments.},
DOI = {10.32604/biocell.2022.018530}
}