@Article{biocell.2022.020462,
AUTHOR = {FRANCESCO PADUANO, EMANUELA ALTOMARE, BENEDETTA MARRELLI, VINCENZO DATTILO, HAIZAL MOHD HUSSAINI, PAUL ROY COOPER, MARCO TATULLO},
TITLE = {Translational aspects of the modern genetics in head and neck cancers},
JOURNAL = {BIOCELL},
VOLUME = {46},
YEAR = {2022},
NUMBER = {8},
PAGES = {1827--1835},
URL = {http://www.techscience.com/biocell/v46n8/47570},
ISSN = {1667-5746},
ABSTRACT = {Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN)
category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific
community. GWAS have identified several pathways involved in the interactions among general risk factors and
genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within
the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis,
involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases have
been systematically investigated for original articles published in the last two years, reporting studies on the main
queries addressed in this work. This review also comparatively describes the impact of environmental and
pathological co-factors in different types of cancers, clarifying and updating the role of genetic factors in SCCHN
onset and development. The main outcomes reported may be helpful to drive clinicians towards their clinical
evaluations for the most appropriate therapeutic approach in SCCHN.},
DOI = {10.32604/biocell.2022.020462}
}