@Article{biocell.2022.022689,
AUTHOR = {YINGHUI GAO, DENGTAI WEN, SHIJIE WANG, JINGFENG WANG},
TITLE = {Presenilin and Alzheimer’s disease interactions with aging, exercise and high-fat diet: A systematic review},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {1},
PAGES = {41--49},
URL = {http://www.techscience.com/biocell/v47n1/49924},
ISSN = {1667-5746},
ABSTRACT = {Presenilin (<i>Psn</i>) protein is associated with organismal aging. Mutations in the <i>Psn</i> gene may lead to Alzheimer’s
disease (AD), dilated cardiomyopathy (DCM), and many age-dependent degenerative diseases. These diseases seriously
affect the quality of life and longevity of the population and place a huge burden on health care and economic systems
around the world. Humans have two types of <i>Psn</i>, presenilin-1 (PSEN1) and presenilin-2 (PSEN2). Mutations in the
genes encoding PSEN1, PSEN2, and amyloid precursor protein (APP) have been identified as the major genetic
causes of AD. <i>Psn</i> is a complex gene strongly influenced by genetic and environmental factors. The effects of exercise,
training, and a high-fat diet on the <i>Psn</i> gene expressed in the heart and its related pathways are not fully understood.
Fortunately, relevant aspects of the mutational effects on <i>Psn</i> can be studied experimentally in easily handled animal
models, including Drosophila, mice, and other animals, all of which share orthologous genes of <i>Psn</i> with humans.
Many previous studies have linked aging, exercise training, and a high-fat diet to the <i>Psn</i> gene. This review discusses
the interrelationship between aging, exercise training, and a high-fat diet on the <i>Psn</i> gene and its associated disease,
AD. The aim is to understand the adverse effects of <i>Psn</i> gene mutations on the body and the diseases caused by AD,
find ways to alleviate the adverse effects and provide new directions for the improvement of treatment strategies for
diseases caused by <i>Psn</i> gene mutations.},
DOI = {10.32604/biocell.2022.022689}
}