@Article{biocell.2022.023030, AUTHOR = {WANTONG LIU, DANYANG CHEN, JINGYAO SU, RUILIN ZHENG, RAN KONG, BING ZHU, HAO DONG, YINGHUA LI}, TITLE = {Quercetin induced HepG2 cells apoptosis through ATM/JNK/STAT3 signaling pathways}, JOURNAL = {BIOCELL}, VOLUME = {47}, YEAR = {2023}, NUMBER = {1}, PAGES = {187--194}, URL = {http://www.techscience.com/biocell/v47n1/49929}, ISSN = {1667-5746}, ABSTRACT = {Liver cancer is the seventh most common malignant tumor in the world and is the second highest cause of death due to cancer. Quercetin, a flavonoid with low toxicity, widely exists in various fruits and vegetables. It has the potential to be a therapeutic agent against various cancers. This study aimed to demonstrate the anti-tumor effect of quercetin on HepG2 cells. Quercetin suppressed the HepG2 cell proliferation in a dose-dependent manner in cell viability assay. Induction of cell apoptosis was confirmed by apoptotic cells population (sub-G1 peak) detected by flow cytometer. A decrease in mitochondrial membrane potential and caspase-3 activation were also demonstrated in this study. Furthermore, quercetin induced HepG2 cell apoptosis through ROS-mediated phosphorylated ataxia-telangiectasia mutated, c-Jun Nterminal kinases, signal transducer, and activator of transcription 3 (STAT-3), and Bax signaling pathways. These results suggest that quercetin has the potential to become an effective drug against the tumor.}, DOI = {10.32604/biocell.2022.023030} }