@Article{biocell.2022.023568,
AUTHOR = {TIANXING LIU, HONGYAN DIAO},
TITLE = {A double-edged sword: The HBV-induced non-coding RNAs alterations in hepatocellular carcinoma},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {1},
PAGES = {27--32},
URL = {http://www.techscience.com/biocell/v47n1/49930},
ISSN = {1667-5746},
ABSTRACT = {Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression,
oncogenesis, and many other pathologies. Hepatitis B virus (HBV) infection is a leading cause of hepatocellular
carcinoma (HCC), and some studies have shown that the expression of non-coding RNAs has an assignable effect on
the development of HBV-induced HCC. In this context, the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing attention. This review
covers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNA
expression, cataloging the recent reports about the roles of non-coding RNAs in HBV-induced hepatoma into five
classes, including (1) modulation of metabolism in hepatic cancer, (2) aggravation of inflammation and hepatic
fibrosis, (3) alteration of the tumor immune microenvironment, (4) non-coding RNA N6-methyladenosine
modification, and a seemingly opposite process, (5) the suppression of the progression of HBV-related HCC. All
evidence supports non-coding RNAs as promising novel targets for the early diagnosis and treatments for HCC.},
DOI = {10.32604/biocell.2022.023568}
}