@Article{biocell.2023.024625,
AUTHOR = {JESSICA CRISTINA MARÍN-LLERA, CARLOS AMAURY JIMÉNEZ-CÁRDENAS, JESÚS CHIMAL-MONROY},
TITLE = {Control of tendon cell fate in the embryonic limb: A molecular perspective},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {3},
PAGES = {465--471},
URL = {http://www.techscience.com/biocell/v47n3/51082},
ISSN = {1667-5746},
ABSTRACT = {The molecular cascade underlying tendon formation starts when progenitor cells begin to express the <i>Scleraxis</i> (<i>Scx</i>) gene. <i>Scx</i> knockout mice develop some but not all tendons, suggesting that additional factors are necessary for tendon commitment, maintenance, and differentiation. Other transcription factors, such as <i>Mohawk</i> (<i>Mkx</i>) or early growth response (<i>Egr</i>), maintain <i>Scx</i> expression and extracellular matrix formation during fibrillogenesis. The inhibition of wingless and int-related protein signaling is necessary and sufficient to induce the expression of <i>Scx</i>. Once the commitment of tenogenic lineage occurs, transforming growth factor-beta (TGFβ) induces the <i>Scx</i> gene expression, becoming involved in the maintenance of tendon cell fate. From this point of view, we discussed two phases of the tenogenic process during limb development: dependent and independent of mechanical forces. Finally, we highlight the importance of understanding embryonic tendon development to improve therapeutic strategies in regenerative medicines for tendons.},
DOI = {10.32604/biocell.2023.024625}
}