@Article{biocell.2023.026698,
AUTHOR = {QIAO ZHOU, JIAN LIU, LING XIN, YANYAN FANG, LEI WAN, DAN HUANG, JINCHEN GUO, JIANTING WEN},
TITLE = {DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {4},
PAGES = {761--772},
URL = {http://www.techscience.com/biocell/v47n4/51797},
ISSN = {1667-5746},
ABSTRACT = {The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age,
environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not
adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and
crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental
risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has
been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease
progression and medication response, as shown in this research. This review aims to update knowledge in the field of
DNA methylation associated with OA to better identify the essential features of OA subtypes and pathological
conditions, hence accelerating individualized treatment and precision medicine.},
DOI = {10.32604/biocell.2023.026698}
}