TY  - EJOU
AU  - ZHOU, QIAO 
AU  - LIU, JIAN 
AU  - XIN, LING 
AU  - FANG, YANYAN 
AU  - WAN, LEI 
AU  - HUANG, DAN 
AU  - GUO, JINCHEN 
AU  - WEN, JIANTING 

TI  - DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review
T2  - BIOCELL

PY  - 2023
VL  - 47
IS  - 4
SN  - 1667-5746

AB  - The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age,
environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not
adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and
crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental
risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has
been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease
progression and medication response, as shown in this research. This review aims to update knowledge in the field of
DNA methylation associated with OA to better identify the essential features of OA subtypes and pathological
conditions, hence accelerating individualized treatment and precision medicine.
KW  - Epigenetics
KW  -  DNA methylation
KW  -  Osteoarthritis
KW  -  Pathogenesis
KW  -  Precision medicine

DO  - 10.32604/biocell.2023.026698