@Article{biocell.2023.027027,
AUTHOR = {ZHENG CAO, CHUNXIAO ZHOU, ZHIMIN WU, CHUNYAN WU, WEN ZHANG, SHILV CHEN, XINDONG ZHAO, SHAOLING WU},
TITLE = {Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {5},
PAGES = {1075--1083},
URL = {http://www.techscience.com/biocell/v47n5/52272},
ISSN = {1667-5746},
ABSTRACT = {<b>Background:</b> Dihydroartemisinin (DHA) is reported to be a potential anticancer agent, and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure. This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis. <b>Methods:</b> Here, the Cell Counting Kit 8 assay was conducted to study cell proliferation. We performed Annexin V-FITC/propidium iodide staining, real-time polymerase chain reaction, and western blot analysis to analyze cell apoptosis and potential molecular mechanisms. <b>Results:</b> The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis <i>in vitro</i> in a time- and concentration-dependent fashion. Moreover, STAT3 activity could be inhibited after stimulation with DHA. <b>Conclusion:</b> These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling pathway. In addition, DHA might be an effective drug for diffuse large B cell lymphoma therapy.},
DOI = {10.32604/biocell.2023.027027}
}