TY  - EJOU
AU  - CAO, ZHENG 
AU  - ZHOU, CHUNXIAO 
AU  - WU, ZHIMIN 
AU  - WU, CHUNYAN 
AU  - ZHANG, WEN 
AU  - CHEN, SHILV 
AU  - ZHAO, XINDONG 
AU  - WU, SHAOLING 

TI  - Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity
T2  - BIOCELL

PY  - 2023
VL  - 47
IS  - 5
SN  - 1667-5746

AB  - <b>Background:</b> Dihydroartemisinin (DHA) is reported to be a potential anticancer agent, and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure. This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis. <b>Methods:</b> Here, the Cell Counting Kit 8 assay was conducted to study cell proliferation. We performed Annexin V-FITC/propidium iodide staining, real-time polymerase chain reaction, and western blot analysis to analyze cell apoptosis and potential molecular mechanisms. <b>Results:</b> The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis <i>in vitro</i> in a time- and concentration-dependent fashion. Moreover, STAT3 activity could be inhibited after stimulation with DHA. <b>Conclusion:</b> These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling pathway. In addition, DHA might be an effective drug for diffuse large B cell lymphoma therapy.
KW  - Diffuse large B cell lymphoma; Dihydroartemisinin; STAT3; Cell apoptosis

DO  - 10.32604/biocell.2023.027027