@Article{biocell.2023.028222,
AUTHOR = {ZICHEN SHAO, CHUNG-YI CHEN, XUZHOU CHEN, HANWU CHEN, MENGQIAO SU, HUI SUN, YIDAN LI, BINGHUA TU, ZITONG WANG, CHI-MING LIU},
TITLE = {Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {6},
PAGES = {1389--1396},
URL = {http://www.techscience.com/biocell/v47n6/52783},
ISSN = {1667-5746},
ABSTRACT = {<b>Background:</b> Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Enlargement of the prostate causes lower urinary tract symptoms. Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. <b>Methods:</b> Our study investigated the effect of capsaicin <i>in vitro</i> and in a mouse model <i>in vivo</i>. A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10–100 µM) for 24 and 48 h. Capsaicin (10–100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. The testosterone propionate (7.5 mg/kg)-induced BPH mouse model was used to examine the anti-proliferative effect of capsaicin. Treatment with capsaicin (10 mg/kg) for 14 days significantly attenuated prostatic hyperplasia. Finasteride was used as a positive control. <b>Results:</b> Capsaicin significantly decreased prostate weight and prostate index (prostate/body weight ratio) in BPH mice. The expression of 5α-reductase type II, androgen receptor (AR) and prostate specific antigen (PSA) protein expression and PSA serum were all significantly reduced in capsaicin-treated BPH mice. In addition, capsaicin also activated transient receptor potential vanilloid 1 mediated apoptosis and autophagy in BPH mice. <b>Conclusion:</b> These results demonstrate multiple positive effects of capsaicin in controlling prostate growth and suggest its therapeutic potential in the treatment of BPH.},
DOI = {10.32604/biocell.2023.028222}
}