@Article{biocell.2023.027201,
AUTHOR = {YUTING WANG, PEIWEN FAN, YANING FENG, XUAN YAO, YANCHUN PENG, RUOZHENG WANG},
TITLE = {Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction},
JOURNAL = {BIOCELL},
VOLUME = {47},
YEAR = {2023},
NUMBER = {6},
PAGES = {1365--1375},
URL = {http://www.techscience.com/biocell/v47n6/52793},
ISSN = {1667-5746},
ABSTRACT = {<b>Background:</b> This study was designed to investigate the feasibility of tumor-infiltrating immune cells with
different phenotypic characteristics for predicting short-term clinical responses in patients with locally advanced
cervical cancer (LACC). <b>Methods:</b> Thirty-four patients who received concurrent chemoradiotherapy and twenty-one
patients who merely underwent radiotherapy were enrolled in this study. We retrospectively analyzed the T cell
markers (i.e., CD3, CD4, CD8), memory markers (i.e., CD45, CCR7), and differentiation markers (i.e., CD27) in the
peripheral blood and tumor tissues of patients with LACC before treatment based on flow cytometry. We also
analyzed the relationship of T cell subsets between peripheral blood and tumor tissues, and their correlation with
complete response or partial response. <b>Results:</b> The percentage of central memory CD8<sup>+</sup>
TCM
(CD8<sup>+</sup>
CD45RA<sup>−</sup>
CD27<sup>+</sup>
CCR7<sup>+</sup>
) cells in LACC patients was significantly lower than that of the control group. The
percentage of CD8<sup>+</sup>
TN in the peripheral blood of LACC patients was significantly higher than that of tumor tissues.
CD8<sup>+</sup>
TEM in the peripheral blood was significantly lower than that of tumor tissues. The percentage of CD8<sup>+</sup>
TN and
CD8<sup>+</sup>
TCM in human papillomavirus (HPV) positive samples was significantly higher than that of HPV-negative
samples. Similarly, the percentage of CD8<sup>+</sup>
TCM in tumor tissues was significantly higher in cancer tissue samples
with lymph nodes compared with those without. <b>Conclusion: </b>A higher proportion of CD4<sup>+</sup>
TCM and a lower
proportion of CD8<sup>+</sup>
TN in the tumor microenvironment of LACC may contribute to the therapy response prediction.},
DOI = {10.32604/biocell.2023.027201}
}