TY  - EJOU
AU  - PANG, SHUOCHEN 
AU  - JIA, TAO 
AU  - YANG, ZIFENG 

TI  - Unraveling the RAGE axis in pulmonary disorders: Mechanisms and therapeutical potential
T2  - BIOCELL

PY  - 2024
VL  - 48
IS  - 12
SN  - 1667-5746

AB  - The Receptor for Advanced Glycation End Products (RAGE) is a multiligand receptor of the immunoglobulin superfamily, notably highly expressed in the lungs. Its interaction with a variety of ligands, including advanced glycation end products (AGEs), S100 proteins, and high mobility group box 1 (HMGB1), activates multiple signaling pathways that are pivotal in the pathogenesis of numerous pulmonary diseases and comorbidities. However, comprehensive reviews on the role of ligands-RAGE signaling in specific lung diseases are rare. This review aims to elucidate the mechanisms by which RAGE-mediated signaling pathways either provide protective or pathogenic effects in pulmonary diseases, focusing on its key regulatory roles in asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), Lung Cancer and COVID-19 Pneumonia, as well as to discuss its therapeutic potential in the specific context of lung diseases.
KW  - AGE; MAPK; NF-κB; RAGE ligands; Pulmonary diseases

DO  - 10.32604/biocell.2024.055753