TY  - EJOU
AU  - LIU, TINGTING 
AU  - KONG, XIANGRUI 
AU  - WEI, JIANSHE 

TI  - Unraveling the molecular crossroads: T2DM and Parkinson’s disease interactions
T2  - BIOCELL

PY  - 2024
VL  - 48
IS  - 12
SN  - 1667-5746

AB  - Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. In recent times, an elevated risk of Parkinson’s disease (PD) development among individuals with T2DM has become evident. However, the molecular mechanisms that underpin the interplay between T2DM and the pathogenesis of PD remain to be elucidated. Nevertheless, recent epidemiological studies have underscored several shared molecular pathways that are crucial for normal cellular function and are also associated with the progression and etiology of both T2DM and PD. This review encapsulates some of the shared pathophysiological mechanisms, including genetic risk factors, hyperglycemia, insulin resistance (IR), inflammation, mitochondrial dysfunction, oxidative stress, autophagy, and advanced glycation end products (AGEs), which independently contribute to the onset and progression of T2DM and PD. Additionally, this review compiles studies that have investigated the relationship between T2DM and PD. This review aims to offer insights into the overlapping molecular pathways involved, which may suggest alternative therapeutic strategies for both T2DM and PD.
KW  - Type 2 diabetes mellitus; Parkinson’s disease; Oxidative stress; Mitochondrial dysfunction; Autophagy

DO  - 10.32604/biocell.2024.056272