TY  - EJOU
AU  - SINGH, GARIMA 
AU  - SHARMA, SONIKA KUMARI 
AU  - MISHRA, NEELU 
AU  - SONI, AASTHA 
AU  - KUMARI, MANSHI 
AU  - SINGH, SAMARENDRA KUMAR 

TI  - Targeting cell cycle regulators: A new paradigm in cancer therapeutics
T2  - BIOCELL

PY  - 2024
VL  - 48
IS  - 12
SN  - 1667-5746

AB  - Dysregulation of the cell cycle is a molecular hallmark of cancer, which leads to uncontrolled proliferation and self-renewal of neoplastic cells. To maintain this phenotype, cells acquire multiple molecular alterations and bypass several cellular checkpoints that are involved in the prevention of genomic instability and uncontrolled cell proliferation. Therefore, targeting cell cycle regulators could prove to be a promising anti-cancer approach. Recent advancements in the understanding of cancer cell susceptibilities have revealed a therapeutic opportunity to selectively target the cell cycle in malignant cells. This review highlights major cell cycle dysregulation in cancerous cells and the latest developments on anti-cancer agents that target cell cycle factors which are either in clinical practice or in clinical trials at present. In light of increasing drug resistance in cancer patients, the article also discusses mechanistic insights for the exploration of probable therapies that could be used to target these cell cycle factors. Additionally, it outlines the future research necessary to develop new therapies and optimize existing ones to achieve maximum efficacy. Thus, this article aims to provide a comprehensive understanding of the advancements in cancer therapies targeting dysregulated cell cycle factors.
KW  - Cyclins; Cyclin-dependent kinases; Taxanes; Cell cycle inhibitors; Targeted therapy

DO  - 10.32604/biocell.2024.056503