TY  - EJOU
AU  - MA, JINNI 
AU  - ZHOU, MEILIN 
AU  - XU, XIN 
AU  - GAO, XINYAO 
AU  - WANG, HAIXIA 
AU  - SHEN, JINHUA 
AU  - XUE, LU 

TI  - Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers
T2  - BIOCELL

PY  - 2024
VL  - 48
IS  - 2
SN  - 1667-5746

AB  -  <b>Background:</b> Placenta specific 8 (PLAC8) is a candidate oncogene involved in the development and progression of solid tumors. However, the status of PLAC8 in lung cancer (LC), especially non-small cell lung cancer (NSCLC) is still not lucid. <b>Methods:</b> Tissue microarray analysis (TMA) was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines. Then a series of cellular experiments were performed fto assess cell proliferation, cell cycle profiles, and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines: H1299 and A549. <b>Results:</b> TMA results showed that PLAC8 played complex and even contradictory roles in different LC samples. Detailed cell-based experiments confirmed that PLAC8 could promote cell viability, alter the cell cycle, and accelerate cell mobility by regulating cell cyclins or cadherins, respectively. <b>Conclusions:</b> The study findings indicate that PLAC8 might participate in LC, especially NSCLC, by affecting cellular physiological processes. The outcomes also shed new light on the potential role of PLAC8 as a therapeutic biomarker in NSCLC.
KW  - PLAC8; Lung cancer; Non-small cell lung cancer; Cell proliferation; Cell migration

DO  - 10.32604/biocell.2023.045076