TY  - EJOU
AU  - LUO, CHENG-GONG 
AU  - ZHANG, JIAO 
AU  - AN, YUN-ZHAO 
AU  - LIU, XUAN 
AU  - LI, SHUAI-JIE 
AU  - ZHANG, WEI 
AU  - LI, KAI 
AU  - ZHAO, XU 
AU  - YUAN, DONG-BO 
AU  - AN, LING-YUE 
AU  - CHEN, WEI 
AU  - TIAN, YE 
AU  - XU, BIN 

TI  - MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression
T2  - BIOCELL

PY  - 2024
VL  - 48
IS  - 5
SN  - 1667-5746

AB  - <b>Background:</b> Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. <b>Methods:</b> A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays, as well as animal studies conducted <i>in vivo</i>. Additionally, we conducted further experiments involving ferroptosis-related analysis to validate its association with ferroptosis. <b>Results:</b> The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa patients. Mitogen-activated protein kinase 9 (MAPK9) emerged as a crucial gene within the model. <i>In vivo</i> and <i>in vitro</i> experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and proliferation. <b>Conclusion:</b> The findings provide a novel perspective for advancing ferroptosis exploration in PCa, bridging basic research and clinical applications.
KW  - Ferroptosis; Biochemical recurrence; Prostate cancer; TCGA; GEO; MAPK9

DO  - 10.32604/biocell.2024.048878