TY  - EJOU
AU  - YOU, YIXIAN 
AU  - LEE, YIHUNG 
AU  - HU, YUSHIN 
AU  - XU, YOUHUI 
AU  - CHEN, JOU 
AU  - JIANG, WEI 
AU  - LIU, CHANGHAI 
AU  - CHEN, ENQIANG 
AU  - TANG, HONG 
AU  - ZHANG, HUA 
AU  - WU, DONGBO 

TI  - Development and application prospect of stem cell combined with 3D printing technology for oral disease
T2  - BIOCELL

PY  - 2025
VL  - 49
IS  - 1
SN  - 1667-5746

AB  - 
With organ transplantation facing many dilemmas, tissue and organ regeneration as an alternative has bright prospects. In regenerative medicine, Three-dimensional (3D) printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry, respectively. However, there are very few studies on the combination of the two, and even fewer clinical studies have been reported in dentistry. In this review, the current oral tissue engineering <i>in vivo</i> and <i>in vitro</i> based on 3D printing and stem cell technology will be summarized, and the discussion on the development prospects of this research direction will be given. Besides, the working principles and advantages & disadvantages of several types of 3D printers, as well as the mechanism of stem cells in tissue engineering will be elucidated. This review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related diseases. In the future, 3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies, catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D scaffolds. Consequently, these developments will further advance the field of oral tissue engineering.
KW  - Stem cells; 3D printing; Tissue engineering; Oral diseases

DO  - 10.32604/biocell.2024.057259