@Article{biocell.2025.058038,
AUTHOR = {Mukul Mishra, Deeba Khan, Sehbanul Islam},
TITLE = {E3 Ligases and COVID-19: Insights into Viral Control and Therapeutic Potential},
JOURNAL = {BIOCELL},
VOLUME = {49},
YEAR = {2025},
NUMBER = {1},
PAGES = {127--147},
URL = {http://www.techscience.com/biocell/v49n1/59356},
ISSN = {1667-5746},
ABSTRACT = {The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their modulation by E3 ubiquitin ligases. By dissecting these intricate interactions and the impact of E3 ligases on SARS-CoV-2 infection, we aim to uncover novel therapeutic opportunities and strategies to effectively combat COVID-19.},
DOI = {10.32604/biocell.2025.058038}
}