TY  - EJOU
AU  - Mishra, Mukul 
AU  - Khan, Deeba 
AU  - Islam, Sehbanul 

TI  - E3 Ligases and COVID-19: Insights into Viral Control and Therapeutic Potential
T2  - BIOCELL

PY  - 2025
VL  - 49
IS  - 1
SN  - 1667-5746

AB  - The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their modulation by E3 ubiquitin ligases. By dissecting these intricate interactions and the impact of E3 ligases on SARS-CoV-2 infection, we aim to uncover novel therapeutic opportunities and strategies to effectively combat COVID-19.
KW  - SARS-CoV-2; COVID-19; viral proteins; host-pathogen interaction; E3 ubiquitin ligases; ubiquitination; targeted protein degradation

DO  - 10.32604/biocell.2025.058038