TY  - EJOU
AU  - Wang, Qing 
AU  - Cai, Luyao 
AU  - Tang, Shouyi 
AU  - Pan, Dan 
AU  - Wang, Zhen 
AU  - Chen, Qianming 
AU  - Zhou, Yu 
AU  - Shen, Yingqiang 

TI  - Phospholipid Metabolism Reprogramming of Cancer Stem Cells and Its Impacts on Stemness
T2  - BIOCELL

PY  - 2025
VL  - 49
IS  - 4
SN  - 1667-5746

AB  - Cancer Stem Cells (CSCs) are cancer cells with self-renewal and tumorigenesis abilities. CSCs in tumor tissues are the leading cause of tumor progression, recurrence, and drug resistance. CSCs have distinct metabolic features that contribute to maintaining their self-renewal and stemness. Phospholipids are essential components of cell membranes and play fundamental roles in cellular activities. CSCs have abnormal phospholipid metabolism, which affects their self-renewal, differentiation, invasion, and drug resistance. Compared with non-CSCs, the phospholipid metabolism of CSCs mainly focused on significantly increased fatty acid (FAs) and phospholipids synthesis, phospholipid unsaturation, and lipolysis-fatty acid oxidation (FAO). In brief, FA and phospholipid metabolism in the anabolic and catabolic pathways are strictly regulated in CSCs to maintain self-renewal and stemness activity. In this review, we summarize the alterations in phospholipid metabolism in CSCs and their impacts on the stemness of CSCs, and we put forward the potential applications of targeting phospholipid metabolism for CSCs, to provide directions for the development of drugs targeting the phospholipid metabolism.
KW  - Neoplastic stem cells; cancer stem cells; phospholipids; phosphatides; metabolism

DO  - 10.32604/biocell.2025.060045