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Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy

Kari L. Turkowski1, David J. Tester2,3, J. Martijn Bos2,4, Kristina H. Haugaa5, Michael J. Ackerman2,3,4

1 Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA
2 Department of Molecular Pharmacology & Experimental Therapeutics; Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, USA
3 Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, Minnesota, USA
4 Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA
5 Center for Cardiological Innovation, Department of Cardiology, Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Oslo Norway and University of Oslo, Oslo, Norway

* Corresponding Author:Michael J. Ackerman, M.D., Ph.D., Windland Smith Rice Sudden Death Genomics Laboratory, Guggenheim 501, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Email: email

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