The rapid increase in the number of patients with congenital heart disease (CHD) is a serious medical care problem [
Patients with CHD frequently have cardiac-specific residual physiologic/anatomic abnormalities and cardiac and non-cardiac sequelae (e.g., arrhythmia, protein-losing enteropathy after Fontan-type operation); furthermore, most of these patients are not completely cured postoperatively [
Establishing patient safety systems, including rapid response systems (RRS) for detecting and responding to acute deterioration in patients with CHD, is of priority. An RRS is designed to improve patient outcomes, with specialized teams of critical care-trained professionals working to identify hospitalized patients whose conditions are deteriorating as early as possible in order to prevent serious adverse events, such as cardiac arrest and unexpected death; it consists of four components (afferent, efferent, process improvement and administrative) [
This retrospective observational study included data obtained from Japan’s In-Hospital Emergency Registry (IHER-J). Institutions are not required to participate in the registry, and the registration items were revised in 2017. In this revision, no changes were made to definitions, classifications, or registration methods. The old database was used from February 2014 to October 2017, and the new database since November 2017. These databases were securely managed by the University Hospital Medical Information Network–Clinical Trial Registry of Tokyo University (Tokyo, Japan), and anonymized data were provided to investigators who submitted research protocols following approval by the IHER-J steering committee. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in a priori approval by the institution’s human research committee; it was reviewed and approved by the ethics committees of all 35 participating hospitals in Japan (reference number: 2498 in St. Mariana University School of Medicine, Japan, the representative for IHER-J). The need to obtain informed consent from patients was waived because of the retrospective nature of the study.
We included consecutive patients registered in the IHER-J who required RRS activations at 35 hospitals in Japan between January 2014 and March 2018 and had CHD. Only patients with a pre-existing CHD diagnosis were considered to have CHD.
Several types of data were collected from the IHER-J database. Demographic data included age, sex, height, weight, and code status before RRS activation. RRS data included RRS activation within one week from surgery, surgery details, member activating RRS, RRS activation location, RRS activation reason, vital signs at RRS activation, RRS intervention, RRS intervention details, time from RRS activation to RRS team arrival, RRS activity time, outcomes at the end of RRS intervention, and outcomes one month after RRS intervention. The following items were additionally included in the new database: main clinical department, diagnosis at admission, cause of deterioration, and ICU admission before RRS activation.
Descriptive statistics were used to summarize the characteristics of deteriorating in-hospital patients who activated an RRS. Continuous variables are expressed as medians with interquartile ranges (IQRs), and categorical variables are expressed as frequencies and percentages. Patients with CHD were divided into two groups: those who died within one month after RRS activation and those who survived. Between-group differences in continuous and categorical variables were compared using the Wilcoxon rank-sum and Fisher’s exact tests, respectively. Multiple logistic regression analyses for age adjustment were performed to examine the associations between 1-month mortality and variables with significant between-group differences; the results were presented as crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs). All
During the study period, 9,607 patients were registered in the IHER-J database (5,884 and 3,723 patients in the old and new databases, respectively). Among the registered patients, 82 (0.9%) had CHD and were included in this study (
Characteristics | All |
Survival |
Death |
|
---|---|---|---|---|
Demographics | ||||
Age in years, median (IQR1) | 1.5 (0, 12) | 1 (0, 12) | 5 (2, 6) | 0.18 |
Age categories in years, n (%) | ||||
<1 | 26 (31.7) | 25 (34.2) | 1 (11.1) | 0.26 |
1–6 | 29 (35.4) | 23 (31.5) | 6 (66.7) | 0.06 |
7–12 | 7 (8.5) | 7 (9.6) | 0 (0) | >0.99 |
13–17 | 5 (6.1) | 5 (6.8) | 0 (0) | >0.99 |
≥18 | 15 (18.3) | 13 (17.8) | 2 (22.2) | 0.66 |
Male sex, n (%) | 52 (63.4) | 47 (64.4) | 5 (55.6) | 0.71 |
Height (cm), median (IQR) | 70 (60, 103) | 70 (60, 103) | 77 (68, 100) | 0.51 |
Weight (kg), median (IQR) | 8.0 (4.5, 12.9) | 7.3 (4.4, 13.2) | 9.9 (7.8, 11.5) | 0.40 |
Main clinical departments | ||||
Pediatrics, n (%) | 21 (25.9) | 21 (29.2) | 0 (0) | 0.10 |
Cardiology, n (%) | 10 (12.3) | 9 (12.5) | 1 (11.1) | >0.99 |
Cardiovascular surgery, n (%) | 8 (9.9) | 7 (9.7) | 1 (11.1) | >0.99 |
Hematology, n (%) | 6 (7.4) | 5 (6.9) | 1 (11.1) | 0.51 |
Gastroenterology, n (%) | 3 (3.7) | 2 (2.8) | 1 (11.1) | 0.30 |
Gastrointestinal surgery, n (%) | 3 (3.7) | 3 (4.2) | 0 (0) | >0.99 |
Respiratory medicine, n (%) | 1 (1.2) | 1 (1.4) | 0 (0) | >0.99 |
Neurology, n (%) | 1 (1.2) | 1 (1.4) | 0 (0) | >0.99 |
Neurosurgery, n (%) | 2 (2.5) | 2 (2.8) | 0 (0) | >0.99 |
Orthopedic surgery, n (%) | 2 (2.5) | 2 (2.8) | 0 (0) | >0.99 |
Others (internal medicine), n (%) | 16 (19.8) | 12 (16.7) | 4 (44.4) | 0.07 |
Others (surgery), n (%) | 8 (9.9) | 7 (9.7) | 1 (11.1) | >0.99 |
Diagnosis on admission | 0.09 | |||
Medical disease (circulatory), n (%) | 13 (29.5) | 13 (30.2) | 0 (0) | |
Medical disease (non-circulatory), n (%) | 8 (18.2) | 8 (18.6) | 0 (0) | |
Infectious disease, n (%) | 11 (25.0) | 11 (25.6) | 0 (0) | |
Surgical disease (circulatory), n (%) | 5 (11.4) | 5 (11.6) | 0 (0) | |
Surgical disease (non-circulatory), n (%) | 2 (4.5) | 1 (2.3) | 1 (100) | |
Malignant tumor, n (%) | 3 (6.8) | 3 (7.0) | 0 (0) | |
Others, n (%) | 2 (4.5) | 2 (4.7) | 0 (0) | |
Code status before RRS2 activation | <0.001 | |||
Full resuscitation, n (%) | 70 (85.4) | 66 (90.4) | 4 (44.4) | |
Partial resuscitation, n (%) | 1 (1.2) | 1 (1.4) | 0 (0) | |
Do not attempt resuscitation, n (%) | 6 (7.3) | 2 (2.7) | 4 (44.4) | |
N/A3, n (%) | 5 (6.1) | 4 (5.5) | 1 (11.1) | |
RRS information | ||||
ICU4 admission before RRS activation, n (%) | 3 (6.8) | 3 (7.0) | 0 (0) | >0.99 |
Within 1 week from operation to RRS activation, n (%) | 10 (12.2) | 10 (14.7) | 0 (0) | 0.59 |
Operation details | 0.72 | |||
Gastrointestinal, n (%) | 3 (27.3) | 3 (30.0) | 0 (0) | |
Orthopedic, n (%) | 2 (18.2) | 2 (20.0) | 0 (0) | |
Respiratory, n (%) | 2 (18.2) | 1 (10.0) | 1 (100) | |
Neurology, n (%) | 1 (9.1) | 1 (10.0) | 0 (0) | |
Cardiovascular, n (%) | 1 (9.1) | 1 (10.0) | 0 (0) | |
Others, n (%) | 2 (18.2) | 1 (10.0) | 0 (0) | |
Members who activated RRS | >0.99 | |||
Physician, n (%) | 15 (22.4) | 14 (23.0) | 1 (16.7) | |
Nurse, n (%) | 50 (74.6) | 45 (73.8) | 5 (83.3) | |
Other medical staff, n (%) | 1 (1.5) | 1 (1.6) | 0 (0) | |
Medical office worker, n (%) | 0 (0) | 0 (0) | 0 (0) | |
Others, n (%) | 1 (1.5) | 1 (1.6) | 0 (0) | |
Places where RRS was activated | >0.99 | |||
General ward, n (%) | 71 (86.6) | 62 (84.9) | 9 (100) | |
Outpatient department, n (%) | 5 (6.1) | 5 (6.8) | 0 (0) | |
Examination room, n (%) | 3 (3.7) | 3 (4.1) | 0 (0) | |
Rehabilitation room, n (%) | 1 (1.2) | 1 (1.4) | 0 (0) | |
Others, n (%) | 2 (2.4) | 2 (2.7) | 0 (0) | |
Reasons for RRS activation | ||||
Desaturation, n (%) | 29 (35.4) | 25 (34.2) | 4 (44.4) | 0.71 |
Any concern, n (%) | 28 (34.1) | 24 (32.9) | 4 (44.4) | 0.48 |
Tachypnoea, n (%) | 21 (25.6) | 21 (28.8) | 0 (0) | 0.10 |
New dyspnea, n (%) | 16 (19.5) | 16 (21.9) | 0 (0) | 0.19 |
Disturbance of consciousness, n (%) | 14 (17.1) | 12 (16.4) | 2 (22.2) | 0.64 |
Tachycardia, n (%) | 8 (9.8) | 8 (11.0) | 0 (0) | 0.58 |
Hypotension, n (%) | 4 (9.1) | 4 (9.3) | 0 (0) | >0.99 |
Bradypnea, n (%) | 3 (3.7) | 3 (4.1) | 0 (0) | >0.99 |
Anaphylaxis, n (%) | 2 (2.4) | 2 (2.7) | 0 (0) | >0.99 |
Convulsive seizure, n (%) | 1 (1.2) | 0 (0) | 1 (11.1) | 0.11 |
Oliguria, n (%) | 1 (1.2) | 1 (1.4) | 0 (0) | >0.99 |
Massive bleeding, n (%) | 1 (2.3) | 0 (0) | 1 (0) | 0.02 |
Causes of deterioration | ||||
Respiratory failure, n (%) | 20 (45.5) | 20 (46.5) | 0 (0) | >0.99 |
Infection, n (%) | 8 (18.2) | 7 (16.3) | 1 (100) | 0.18 |
Suffocation, n (%) | 5 (11.4) | 5 (11.6) | 0 (0) | >0.99 |
Heart failure, n (%) | 4 (9.1) | 4 (9.3) | 0 (0) | >0.99 |
Distributive shock, n (%) | 1 (2.3) | 1 (2.3) | 0 (0) | >0.99 |
Vital signs at RRS activation | ||||
Oxygen saturation (%), median (IQR) | 95.0 (90.0, 98.0) | 97.0 (88.3, 99.0) | 93.0 (88.3, 98.3) | 0.55 |
Respiratory rate (breaths per minute), median (IQR) | 22 (17, 30) | 30 (24, 46) | 20 (18, 26) | 0.01 |
Heart rate (beats per minute), median (IQR) | 93 (73, 116) | 112 (97, 135) | 87 (83, 100) | 0.02 |
Systolic blood pressure (mmHg), median (IQR) | 112 (85, 137) | 97 (88, 116) | 110 (90, 120) | 0.60 |
Diastolic blood pressure (mmHg), median (IQR) | 65 (50, 80) | 58 (48, 69) | 60 (48, 60) | 0.45 |
Body temperature (°C), median (IQR) | 36.9 (36.5, 37.7) | 36.8 (36.3, 37.4) | 36.8 (36.5, 37.3) | 0.94 |
Glasgow Coma Scale score, median (IQR) | 13 (7, 15) | 15.0 (11.5, 15.0) | 11.5 (7.5, 13.3) | 0.04 |
RRS intervention, n (%) | 54 (65.9) | 46 (63.0) | 8 (88.9) | 0.15 |
Details of RRS interventions | ||||
Oxygen inhalation, n (%) | 20 (24.4) | 18 (24.7) | 2 (22.2) | >0.99 |
Bag valve mask ventilation, n (%) | 11 (13.4) | 8 (11.0) | 3 (33.3) | 0.09 |
Suction, n (%) | 10 (12.2) | 8 (11.0) | 2 (22.2) | 0.30 |
Noninvasive positive pressure ventilation, n (%) | 4 (4.9) | 3 (4.1) | 1 (11.1) | 0.37 |
Intubation/mechanical ventilation, n (%) | 9 (11.0) | 7 (9.6) | 2 (22.2) | 0.25 |
Bolus infusion, n (%) | 12 (14.6) | 9 (12.3) | 3 (33.3) | 0.12 |
Drug administration, n (%) | 13 (15.9) | 10 (13.7) | 3 (33.3) | 0.14 |
Request for some examinations, n (%) | 14 (17.1) | 11 (15.1) | 3 (33.3) | 0.17 |
Chest compression, n (%) | 2 (2.4) | 2 (2.7) | 0 (0) | >0.99 |
Time from RRS activation to RRS team arrival (minute), median (IQR) | 5.0 (3.0, 15.0) | 5.0 (2.8, 15.0) | 7.0 (4.0, 10.0) | 0.62 |
RRS activity time (minute), median (IQR) | 20.0 (13.5, 39.3) | 20.0 (11.8, 33.5) | 36.5 (19.3, 56.3) | 0.06 |
Outcomes at the end of RRS intervention | 0.09 | |||
No transfer, n (%) | 58 (70.7) | 53 (72.6) | 5 (55.6) | |
Transfer to ICU, n (%) | 17 (20.7) | 15 (20.5) | 2 (22.2) | |
Transfer to high care ward other than ICU, n (%) | 3 (3.7) | 2 (2.7) | 1 (11.1) | |
Transfer to a different hospital, n (%) | 0 (0) | 0 (0) | 0 (0) | |
Death, n (%) | 1 (1.2) | 0 (0) | 1 (11.1) | |
Others, n (%) | 2 (2.4) | 2 (2.7) | 0 (0) | |
Outcomes a month after RRS intervention | <0.001 | |||
Survival at home, n (%) | 35 (42.7) | 35 (47.9) | 0 (0) | |
Survival in the hospital, n (%) | 38 (46.3) | 38 (52.1) | 0 (0) | |
Death, n (%) | 9 (11.0) | 0 (0) | 9 (100) |
Note: 1IQR, interquartile range; 2RRS, rapid response system; 3N/A, not applicable; 4ICU, intensive care unit.
The median age of patients with CHD was 1.5 years (IQR, 0–12 years); approximately 70% and 20% of the patients were aged <7 years and ≥18 years, respectively. Pediatrics was the most commonly cited clinical department (25.9%), followed by internal medicine, cardiology, cardiovascular surgery, and hematology departments (19.8%, 12.3%, 9.9%, and 7.4%, respectively). The main diagnoses on admission were circulatory disease (29.5%) and infectious disease (25.0%). The majority (85.4%) of patients with CHD opted for a code status of ‘full resuscitation’; 7.3% had ‘DNAR’.
We noted few RRS activations for patients with CHD after ICU discharge or surgery (6.8% and 12.2%, respectively). Regarding patients with CHD who required RRS activation after surgery, the most common surgery was gastrointestinal surgery (27.3%), followed by orthopedic (18.2%) and respiratory surgeries (18.2%); few patients required RRS activation after cardiovascular surgery (9.1%). The RRS was activated most often by a nurse (74.6%); physicians accounted for approximately 20% of all RRS activations. The main reasons for RRS activation were related to respiratory concerns (desaturation, tachypnoea, and new dyspnea) and general concern for the patient, even in the absence of vital sign abnormalities. Respiratory failure and infection were the most common reasons for clinical deterioration (45.5%, and 18.2%, respectively); heart failure was the reason for deterioration in 9.1% of patients. Among patients with CHD, 65.9% underwent RRS interventions. The following is a list of RRS interventions in descending order of frequency: oxygen administration, request for additional examinations, drug administration, and bolus infusion (24.4%, 17.1%, 15.9%, and 14.6%, respectively); 11.0% of the patients with CHD required intubation/mechanical ventilation. The outcomes at the end of the RRS intervention were as follows: most patients with CHD (70.7%) did not require in-hospital transfer to a higher medical care unit, approximately 20% of patients required transfer to ICU, and the mortality rate was 1.2%. One month after the RRS intervention, the patient survival rate was 89.0% (47.9% of the patients who survived were discharged, and 52.1% remained hospitalized); the mortality rate was 11.0%.
We divided the 82 registered patients with CHD into a 1-month mortality group (n = 9) and a survival group (n = 73) (
Vital signs at RRS1 activation | 1-month mortality (n = 9) |
Survival (n = 73) |
Crude OR2 |
Adjusted OR* |
---|---|---|---|---|
Oxygen saturation (%) | 93.0 (88.3, 98.3) | 97.0 (88.3, 99.0) | 1.01 (0.95–1.07) | 1.02 (0.99–1.05) |
Respiratory rate (breaths per minute) | 20 (18, 26) | 30 (24, 46) | 1.10 (1.02–1.19)# | 1.10 (1.02–1.19)# |
Heart rate (beats per minute) | 87 (83, 100) | 112 (97, 135) | 1.02 (1.00–1.04)# | 1.02 (1.00–1.04)# |
Systolic blood pressure (mmHg) | 110 (90, 120) | 97 (88, 116) | 1.0 (0.98–1.02) | 0.99 (0.98–1.02) |
Diastolic blood pressure (mmHg) | 60 (48, 60) | 58 (48, 69) | 0.98 (0.94–1.02) | 1.02 (0.99–1.05) |
Body temperature (°C) | 36.8 (36.5, 37.3) | 36.8 (36.3, 37.4) | 1.09 (0.51–2.34) | 1.03 (0.99–1.06) |
Glasgow Coma Scale score | 11.5 (7.5, 13.3) | 15.0 (11.5, 15) | 0.9 (0.75–1.07) | 0.88 (0.73–1.06) |
Note: *Adjusted for in the logistic regression analyses were age (years). #The effect of a one-unit decrease in the vital sign on 1-month mortality is shown. 1RRS, rapid response system; 2OR, odds ratio; 3CI, confidence interval; 4IQR, interquartile range.
This retrospective Japanese database study sought to clarify the actual condition of in-hospital patients with CHD who required RRS activation. First, only 0.9% of the patients who needed RRS in the Japanese multicenter registry had CHD. Moreover, few of these patients were from the cardiology and cardiovascular surgery clinical departments. Few patients required RRS activation after ICU discharge or postoperatively (6.8% and 12.2%, respectively). Second, the most common reason for RRS activation in patients with CHD was respiratory distress. Slightly fewer than 70% of the patients required therapeutic RRS intervention, and approximately 20% of the patients were transferred to the ICU. Furthermore, the mortality rates at the end of RRS intervention and within one month after RRS intervention were 1.2% and 11.0%, respectively. Finally, 1-month mortality was significantly associated with lower HR and lower RR at RRS activation.
The results of the first group of findings mentioned above indicate that the medical staff in the cardiology and cardiovascular surgery clinical departments seldom activated RRS. Japanese institutions have been slow to implement RRS in facilities wherein patients with CHD are treated (in most cases in Japan, such institutions have PICUs). As of 2019, one survey found that only 41.2% of all 34 hospitals in Japan with PICUs had RRSs [
Patients with CHD are at a higher risk of sudden deterioration after cardiac surgery and ICU discharge. The percentages of patients who experienced cardiac arrest, hospital death, and readmission were 2.6%, 4.0% [
A previous report provided a possible reason for the low use of RRSs. Japanese medical culture places high importance on primary care physicians. Further, in Japan, primary care physicians and patients tend to refuse any intervention by third parties, including rapid response teams [
Regarding the second group of findings mentioned above, few patients in this study were patients in perioperative or post-ICU discharge phases, and the primary clinical departments were not cardiology/cardiovascular surgery. Respiratory-related symptoms (desaturation, tachypnoea, and new dyspnea) accounted for approximately 80% of RRS activations. Moreover, respiratory-related disorders, such as respiratory failure and suffocation, were common causes of deterioration in 45.5% and 11.4% of the patients, respectively. A previous study of pediatric cardiac patients—most of whom had undergone cardiac surgery—reported that respiratory symptoms triggered only 25% of rapid-response events; more than half of the events were triggered by other concurrent symptoms of decompensation [
In this study, approximately 70% of deteriorating patients with CHD required RRS activation; intubation/mechanical ventilation and chest compression were required in 11% and 2.4% of deteriorating patients, respectively, and 20.7% of the deteriorating patients were transferred to the ICU. In contrast, a previous study found that pediatric cardiac patients with in-hospital deterioration required more intervention and treatment. Cardiac and/or pulmonary arrest occurred during rapid-response events in 8.5% of the patients, and 22% of the patients required ventilation or vasopressor use within 12 h of transfer to the ICU (defined as ‘critical deterioration events’); moreover, 81% of the patients were transferred to the ICU [
One-month mortality was significantly associated with RR and HR at RRS activation. A previous study showed that single ventricle physiology and ‘critical deterioration events’ are independent predictors of 30-day mortality [
The need to improve the ability of medical systems to effectively manage in-hospital deterioration of patients with CHD is urgent. Our results suggest that RRSs were rarely activated after cardiac surgery and ICU discharge when patients with CHD were at a higher risk of sudden deterioration. Therefore, encouraging the use of RRS in such dangerous situations will enable intervention by a third, specialized team for in-hospital emergencies and provide patients with more comprehensive medical care. A more detailed characterization of hospitalized and actively deteriorating patients with CHD requires a larger sample size, a prospective study design, and the adoption of a larger number of variables for subsequent analysis.
This is the first multicenter report of episodes of in-hospital deterioration requiring RRS in patients with CHD. Contrary to our expectation, there was a high rate of RRS use by departments that do not usually treat congenital heart disease (i.e., other than cardiac surgery and cardiology), a low rate of RRS activation after surgery or ICU discharge, and a high rate of respiratory distress being a reason for RRS activation, which are interesting, new, and previously unreported findings. This study has some limitations. First, there was likely a selection bias as the participating Japanese institutions registered their own data in the database. As of 2019, only four (11.8%) of all 34 hospitals in Japan with pediatric ICUs (PICUs) used the IHER-J [
Using the Japanese multicenter RRS registry, we found that RRS was rarely activated for patients with CHD who were deteriorating after surgery and/or ICU discharge. To improve the prognosis of patients with CHD, it might be beneficial to encourage active use of RRSs during the perioperative period and post-ICU discharge when the risk of deterioration is high. Moreover, the decrease in RR and HR at RRS activation, which was identified as mortality risk in this study, may help in the selection of more appropriate treatment in anticipation of worsening conditions.
St. Marianna University Hospital (Shigeki Fujitani); NHO Ureshino Medical Center (Shinsuke Fujiwara); Kitazato University Hospital (Masayasu Arai); Osaka City General Hospital (Morooka Takaya); Mie University Hospital (Eiji Kawamoto); Nagoya City University Graduate School of Medical Sciences (Yoshiki Sento); Hiroshima Prefectural Hospital (Takao Yamanoue); JA Hiroshima General Hospital (Natsuo Kawamura); Kyoritsu General Hospital (Yuta Kawase); Kobe City Medical Center General Hospital (Kazuma Nagata); Fukushima Medical University Aizu Medical Center (Takuro Saito); Tomishiro Central Hospital (Masahiro Tamashiro); St. Luke’s International Hospital (Kazuhiro Aoki); Hyogo College of Medicine College Hospital (Atsushi Miyawaki); Jichi Medical University Saitama Medical Center (Tomoyuki Masuyama); Shizuoka Children’s Hospital (Tatsuya Kawasaki); Japanese Red Cross Musashino Hospital (Shinichiro Suzaki); Seirei Hamamatsu General Hospital (Takahiro Atsumi); Hikone Municipal Hospital (Tomoyuki Ikeda); Fukushima Medical University Hospital (Kazuo Ouchi); Shimane Prefectural Central Hospital (Yuji Yamamori); Kameda Medical Center (Yoshiro Hayashi); Kurashiki Central Hospital (Takanao Otake); Miyazaki Prefectural Miyazaki Hospital (Takeshi Aoyama); Gunma University Hospital (Masaru Tobe); Okayama Saiseikai General Hospital (Toshifumi Fujiwara); Ibaraki Prefectural Central Hospital (Ryosuke Sekine); Chiba University Graduate School of Medicine (Taka-aki Nakada).
We thank the In-Hospital Emergency Committee in Japan, organized by the patient safety promotion committee in Japanese Society of Emergency Medicine, the rapid response system committee in The Japanese Society of Intensive Care Medicine, Japan Resuscitation Council, Japanese Society of Emergency Paediatrics, The Japanese Circulation Society, Japanese Society for Quality and Safety in Healthcare, and Japanese Coalition for Patient Safety for contribution to this study. We also thank the In-Hospital Emergency Study Group for helping with data collection.