TY  - EJOU
AU  - Sakri, Sapiah 
AU  - Basheer, Shakila 
AU  - Zain, Zuhaira Muhammad 
AU  - Ismail, Nurul Halimatul Asmak 
AU  - Nassar, Dua’ Abdellatef 
AU  - Alohali, Manal Abdullah 
AU  - Alharaki, Mais Ayman 

TI  - Sepsis Prediction Using CNNBDLSTM and Temporal Derivatives Feature Extraction in the IoT Medical Environment
T2  - Computers, Materials \& Continua

PY  - 2024
VL  - 79
IS  - 1
SN  - 1546-2226

AB  -  <b>Background:</b> Sepsis, a potentially fatal inflammatory disease triggered by infection, carries significant health implications worldwide. Timely detection is crucial as sepsis can rapidly escalate if left undetected. Recent advancements in deep learning (DL) offer powerful tools to address this challenge. <b>Aim:</b> Thus, this study proposed a hybrid CNNBDLSTM, a combination of a convolutional neural network (CNN) with a bi-directional long short-term memory (BDLSTM) model to predict sepsis onset. Implementing the proposed model provides a robust framework that capitalizes on the complementary strengths of both architectures, resulting in more accurate and timelier predictions. <b>Method:</b> The sepsis prediction method proposed here utilizes temporal feature extraction to delineate six distinct time frames before the onset of sepsis. These time frames adhere to the sepsis-3 standard requirement, which incorporates 12-h observation windows preceding sepsis onset. All models were trained using the Medical Information Mart for Intensive Care III (MIMIC-III) dataset, which sourced 61,522 patients with 40 clinical variables obtained from the IoT medical environment. The confusion matrix, the area under the receiver operating characteristic curve (AUCROC) curve, the accuracy, the precision, the F1-score, and the recall were deployed to evaluate the models. <b>Result:</b> The CNNBDLSTM model demonstrated superior performance compared to the benchmark and other models, achieving an AUCROC of 99.74% and an accuracy of 99.15% one hour before sepsis onset. These results indicate that the CNNBDLSTM model is highly effective in predicting sepsis onset, particularly within a close proximity of one hour. <b>Implication:</b> The results could assist practitioners in increasing the potential survival of the patient one hour before sepsis onset.
KW  - Temporal derivatives; hybrid deep learning; predicting sepsis onset; MIMIC III; machine learning (ML); deep learning

DO  - 10.32604/cmc.2024.048051