TY - EJOU AU - Umapathi, K. AU - Shobana, S. AU - Nayyar, Anand AU - Justin, Judith AU - Vanithamani, R. AU - Galindo, Miguel Villagómez AU - Ansari, Mushtaq Ahmad AU - Panchal, Hitesh TI - A Novel Approach to Breast Tumor Detection: Enhanced Speckle Reduction and Hybrid Classification in Ultrasound Imaging T2 - Computers, Materials \& Continua PY - 2024 VL - 79 IS - 2 SN - 1546-2226 AB - Breast cancer detection heavily relies on medical imaging, particularly ultrasound, for early diagnosis and effective treatment. This research addresses the challenges associated with computer-aided diagnosis (CAD) of breast cancer from ultrasound images. The primary challenge is accurately distinguishing between malignant and benign tumors, complicated by factors such as speckle noise, variable image quality, and the need for precise segmentation and classification. The main objective of the research paper is to develop an advanced methodology for breast ultrasound image classification, focusing on speckle noise reduction, precise segmentation, feature extraction, and machine learning-based classification. A unique approach is introduced that combines Enhanced Speckle Reduced Anisotropic Diffusion (SRAD) filters for speckle noise reduction, U-NET-based segmentation, Genetic Algorithm (GA)-based feature selection, and Random Forest and Bagging Tree classifiers, resulting in a novel and efficient model. To test and validate the hybrid model, rigorous experimentations were performed and results state that the proposed hybrid model achieved accuracy rate of 99.9%, outperforming other existing techniques, and also significantly reducing computational time. This enhanced accuracy, along with improved sensitivity and specificity, makes the proposed hybrid model a valuable addition to CAD systems in breast cancer diagnosis, ultimately enhancing diagnostic accuracy in clinical applications. KW - Ultrasound images; breast cancer; tumor classification; segmentation; deep learning; lesion detection DO - 10.32604/cmc.2024.047961