TY - EJOU AU - Alrayes, Fatma S. AU - Zakariah, Mohammed AU - Alzaylaee, Mohammed K. AU - Amin, Syed Umar AU - Khan, Zafar Iqbal TI - An Auto Encoder-Enhanced Stacked Ensemble for Intrusion Detection in Healthcare Networks T2 - Computers, Materials \& Continua PY - 2025 VL - 85 IS - 2 SN - 1546-2226 AB - Healthcare networks prove to be an urgent issue in terms of intrusion detection due to the critical consequences of cyber threats and the extreme sensitivity of medical information. The proposed Auto-Stack ID in the study is a stacked ensemble of encoder-enhanced auctions that can be used to improve intrusion detection in healthcare networks. The WUSTL-EHMS 2020 dataset trains and evaluates the model, constituting an imbalanced class distribution (87.46% normal traffic and 12.53% intrusion attacks). To address this imbalance, the study balances the effect of training Bias through Stratified K-fold cross-validation (K = 5), so that each class is represented similarly on training and validation splits. Second, the Auto-Stack ID method combines many base classifiers such as TabNet, LightGBM, Gaussian Naive Bayes, Histogram-Based Gradient Boosting (HGB), and Logistic Regression. We apply a two-stage training process based on the first stage, where we have base classifiers that predict out-of-fold (OOF) predictions, which we use as inputs for the second-stage meta-learner XGBoost. The meta-learner learns to refine predictions to capture complicated interactions between base models, thus improving detection accuracy without introducing bias, overfitting, or requiring domain knowledge of the meta-data. In addition, the auto-stack ID model got 98.41% accuracy and 93.45% F1 score, better than individual classifiers. It can identify intrusions due to its 90.55% recall and 96.53% precision with minimal false positives. These findings identify its suitability in ensuring healthcare networks’ security through ensemble learning. Ongoing efforts will be deployed in real time to improve response to evolving threats. KW - Intrusion detection; auto encoder; stacked ensemble; WUSTL-EHMS 2020 dataset; class imbalance; XGBoost DO - 10.32604/cmc.2025.068599