TY - EJOU AU - Mou, Qiuxiao AU - Gui, Haoyu AU - Tang, Xianghong AU - Lu, Jianguang TI - MCCGAA: Multimodal Channel Compression Graph Attention Alignment Network for ECG Zero-Shot Classification T2 - Computers, Materials \& Continua PY - 2026 VL - 87 IS - 3 SN - 1546-2226 AB - Electrocardiogram (ECG) is a widely used non-invasive tool for diagnosing cardiovascular diseases. ECG zero-shot classification involves pre-training a model on a large dataset to classify unknown disease categories. However, existing ECG feature extraction networks often neglect key lead signals and spatial topology dependencies during cross-modal alignment. To address these issues, we propose a multimodal channel compression graph attention alignment network (MCCGAA). MCCGAA incorporates a channel attention module (CAM) to effectively integrate key lead features and a graph attention-based alignment network to capture spatial dependencies, enhancing cross-modal alignment. Additionally, MCCGAA employs a log-sum-exp loss function, improving classification performance and convergence over the original clip-style method. Experimental results show that MCCGAA outperforms current methods, achieving the highest classification accuracy across six publicly available datasets. MCCGAA holds promise for advancing ECG zero-shot classification and offering better decision support for researchers. KW - ECG zero-shot classification; contrastive learning; cross-modal alignment; graph attention network; channel attention mechanism DO - 10.32604/cmc.2026.076251