@Article{fdmp.2006.002.001,
AUTHOR = {Milica  Radisic, Gordana  Vunjak-Novakovic},
TITLE = {Scaffolds and Fluid Flow in Cardiac Tissue Engineering},
JOURNAL = {Fluid Dynamics \& Materials Processing},
VOLUME = {2},
YEAR = {2006},
NUMBER = {1},
PAGES = {1--16},
URL = {http://www.techscience.com/fdmp/v2n1/24359},
ISSN = {1555-2578},
ABSTRACT = {To engineer cardiac tissue <i>in vitro</i> with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found <i>in vivo</i>. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply.},
DOI = {10.3970/fdmp.2006.002.001}
}