TY - EJOU
AU - Radisic, Milica
AU - Vunjak-Novakovic, Gordana
TI - Scaffolds and Fluid Flow in Cardiac Tissue Engineering
T2 - Fluid Dynamics \& Materials Processing
PY - 2006
VL - 2
IS - 1
SN - 1555-2578
AB - To engineer cardiac tissue in vitro with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found in vivo. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply.
KW -
DO - 10.3970/fdmp.2006.002.001