@Article{10798587.2016.1267241, AUTHOR = {Yichi Zhng, Hongin Wng}, TITLE = {Design of a System to Generate a Four Quadrant Signal at High-Frequency}, JOURNAL = {Intelligent Automation \& Soft Computing}, VOLUME = {24}, YEAR = {2018}, NUMBER = {1}, PAGES = {55--64}, URL = {http://www.techscience.com/iasc/v24n1/39725}, ISSN = {2326-005X}, ABSTRACT = {In order to research biological cells, a well-established physical method can be used, that is electrorotation. To achieve electrorotation system, a signal oscillator or a signal generator is always needed. The signal generator is used for generating signals with phase shift and transfers it to the electro chamber. The frequency range of the output signal is generally between 20 Hz to 100 MHz for the signal generator, but for high frequency range, like 100 MHz to 1 GHz, the signal generator is hard to control and the linear properties for the output signal is not good enough to do the electrorotation. So design a signal generator to generate a signal with high frequency range is indispensable, and this is good for researching the biological cells in high frequency environment. The project finished by doing research for some available signal generators, like Phase-Locked Loop (PLL) and Direct Digital Synthesis (DDS), and the final system with high frequency output signal has been designed after the research. The frequency range of the output signal is between 100 MHz to 1.35 GHz, and the phase shift is 90 degree for the four output signals. The system finally designed is based on analogue circuit, all of the system blocks are designed in Cadence virtuoso software and the CMOS technology is 0.35um. It will affect the big data collection, processing and storing the result of the formation of the entire process.}, DOI = {10.1080/10798587.2016.1267241} }