@Article{icces.2023.09884,
AUTHOR = {Mohamed Abdulsalam, Jiling Feng},
TITLE = {An	In	Vitro	Study	of	Correlation	Between	the	Compositions,	Structure	 and	Mechanical	Properties	of	the	Arterial	Plaque},
JOURNAL = {The International Conference on Computational \& Experimental Engineering and Sciences},
VOLUME = {25},
YEAR = {2023},
NUMBER = {2},
PAGES = {1--1},
URL = {http://www.techscience.com/icces/v25n2/53822},
ISSN = {1933-2815},
ABSTRACT = {Atherosclerosis	developed	in	the	arterial	wall	is	the	major	cause	of	cardiovascular	events	such	as	stroke	and	
heart	 failure.	Atherosclerosis,	also	referred	 to	as	arterial	plaque	can	be	classified	as	stable,	unstable,	and	
vulnerable	 plaque.	 In	 terms	 of	 the	 features	 of	 compositions	 and	 structures,	 atherosclerosis	 also	 can	 be	
classified	as	calcified	plaque,	the	plaque	with	a	lipid	core,	and	plaque	with	a	thin	fibrous	cap.	It	is	expected	
that	the	compositions,	structures,	and	mechanical	properties	of	the	plaques	interrelate	with	each	other.	The	
correlations	between	the	compositions,	structure,	and	mechanical	properties are	expected	to	characterize	
the	 nature	 of	 the	 rupture	 of	 the	 arterial	 plaque	 and	 provide	 important	 clinical	 information.	 To	 date,	
comprehensive	knowledge	about	the	correlation	of	the	compositions,	structure,	and	mechanical	properties	
of	the	plaque	is	lacking.	In	this	project,	various	artificial	arterial	plaques	with	different	compositions	and	
structures	 were	 fabricated.	 Porcine	 fat	 extracted	 when	 it	 was	 exposed	 to	 the	 sun	 at	 30c0,	 was	 used	 to	
represent	the	lipid	core	of	the	artificial	plaque	specimen,	while	gelatine	from	bovine	skin	and	collagen	from	
human	placenta	were	used	to	fabricate	the	fibrous	cap	of	the	specimen.	The	calcification	of	the	specimen	
was	prepared	using	calcium	from	calcium	chloride	hexahydrate	and	collagen.	The	mechanical	properties	of	
eight	types	of	artificial	plaques	were	evaluated	through	the	unconfined	compression	test.	The	experimental	
results	demonstrate	that	the	plaque	with	a	high	percentage	of	collagen	and	with	a	thicker	fibrous	cap	tends	
to	 possess	 the	 large	 Youngs	 Module.	 There is	 a	 strong	 positive	 correlation	 between	 the	 percentage	 of	
collagen,	 the	 thickness	 of	 the	 fibrous	 cap,	 and	 the	 Youngs	 Module	 in	 both	 calcified	 and	 lipid	 plaque.	 A	
negative	correlation	was	found	between	the	percentage	of	lipid	plaque	and	the	Youngs	Module.},
DOI = {10.32604/icces.2023.09884}
}