@Article{icces.2024.011126,
AUTHOR = {Chenyu Liang, Bo Zeng, Mai Tanaka, Andrea Kannita Noy, Matthew Barrett, Erica Hengartner, Abygale Cochrane, Laura Garzon, Mitchell Litvinov, Dietmar Siemann, Xin Tang},
TITLE = {Mechano-Regulated Intercellular Waves Among Cancer Cells},
JOURNAL = {The International Conference on Computational \& Experimental Engineering and Sciences},
VOLUME = {32},
YEAR = {2024},
NUMBER = {1},
PAGES = {1--2},
URL = {http://www.techscience.com/icces/v32n1/58854},
ISSN = {1933-2815},
ABSTRACT = {Cancer accounts for 12.6% of all human deaths worldwide and 90% of cancer-related deaths are due to metastasis: the dissemination of invasive tumor cells from the primary tumors to other vital organs [1-3]. However, how these invasive tumor cells coordinate with each other to achieve the dissemination remains unclear. Recently we discovered that human tumor cells can initiate and transmit previously unknown long-distance (~100s m) intercellular biochemical waves in a microenvironment-mechanics-regulated manner. [4-5] In this presentation, we will present our new results on (1) the 2D/3D spatial-temporal characterization of the long-distance and the intra-/inter-cellular Ca<sup>2+</sup> signals; (2) the functional influences of mechanical microenvironment on the spatial-temporal properties of Ca<sup>2+</sup> dynamics (i.e., signaling symphony); and (3) the molecular mechanisms and biological consequences of the Ca<sup>2+</sup> dynamics during tumor progression and metastasis in vivo. To our knowledge, this study is the 1st report that shows the detailed characterization and mechanistic dissection of long-distance Ca<sup>2+</sup> waves in human cancer cells [4-5]. Our results advance the understanding of the mechano-regulated functions/mechanisms of Ca<sup>2+</sup> signals in human cancer and potentially contribute to the development of new therapies for tumor suppression.},
DOI = {10.32604/icces.2024.011126}
}