Congenital Heart Disease is the first journal focused exclusively on the study and treatment of congenital heart defects in children and adults. It is the official journal of the Children’s Hospital of Nanjing Medical University. We are committed to publishing clinical studies, invited editorials, state-of-the-art reviews, case reports, articles focusing on the history and development of congenital heart disease, and CME material. All manuscripts (including invited) will undergo a rigorous and thorough editorial procedure to promote reliable research findings.
Science Citation Index Expanded (Clarivate Analytics): 2022 Impact Factor: 0.3; Scopus CiteScore (Impact per Publication 2022): 3.9; SNIP (Source Normalized Impact per Paper 2022): 0.930; Journal Citation Report/Science Edition (JCR); etc.
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 571-593, 2023, DOI:10.32604/chd.2024.048939
Abstract The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pediatric nutrition guidelines or consensus worldwide, the management of congenital heart disease, and the results of multi-center clinical nutrition research for congenital heart disease following the first Chinese consensus edition of 2016. The consensus was also shaped by the results of three discussion sessions and two questionnaires conducted by the 13-member collaboration group. This process was informed by both clinical guidelines and expert consensus. The quality of literature, both in English and Chinese, and the level of recommendations were evaluated using the… More >
Open Access
REVIEW
Congenital Heart Disease, Vol.18, No.6, pp. 595-610, 2023, DOI:10.32604/chd.2023.046229
Abstract Background: Congenital absence of pericardium (CAP), also known as pericardial agenesis, represents an uncommon cardiac abnormality and mostly incidental finding. It can be subdivided into complete and partial (left or right-sided) forms. Because of its infrequency, just case reports and a few case series have been released so far. This paper represents the largest systematic review in the field. Nine features (age at diagnosis, type, gender, clinical presentation, electrocardiography, imaging (ultrasounds, CT/MRI), concomitant cardiac defects, and outcome) were analysed. Methods: The electronic database PubMed was investigated from its establishment up to July 15th, 2023. Just case reports and case series… More >
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 611-625, 2023, DOI:10.32604/chd.2023.047689
Abstract Background: Tetralogy of Fallot (TOF) is a very common cyanotic congenital heart disease. Endothelial-to-mesenchymal transition (EndoMT) is recognized as a physiological mechanism involved in embryonic heart development and endothelial formation. However, there is still a gap in the reports related to the mechanism of EndoMT development in TOF. Methods: First, transcriptomic data of single cell nuclei of TOF and Donor were obtained based on the Gene Expression Omnibus (GEO) database, and the data were normalized and clustered by dimensionality reduction using the Seurat package. Subsequently, differentially expressed genes (DEGs) between TOF and Donor were screened using the “FindMarkers” function, and… More >
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 627-638, 2023, DOI:10.32604/chd.2023.030312
Abstract Background: The assessment of Fontan circuit’s flow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions (2D flow), while recently, a single volumetric 4D-flow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart diseases. Purpose: To compare 2D and 4D-flow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential disagreement. Methods: 39 patients after Fontan palliation (23 males, age 22 ± 11 years) who underwent cardiac MRI with 2D and 4D-flow MRI acquisition were included in the study. In all patients, blood flow quantification in the Fontan circuit and aorta… More >
Graphic Abstract
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 639-647, 2023, DOI:10.32604/chd.2023.030065
Abstract Objectives: We investigated whether the selective cerebral perfusion (SCP) technique causes differences in changes in cerebral perfusion between both hemispheres in young infants, using cerebral oxygen saturation (ScO2) as an index. Further, we determined the association between the discrepancy in ScO2 and cerebral perfusion pressure during SCP. Methods: The difference in ScO2 between the left and right cerebral hemispheres (ΔScO2 Rt-Lt) was calculated during clamping of the innominate artery (IA) and during SCP. Results: In 25 infants (aged 2 to 78 days), the left and right ScO2 were well maintained (median 63.2% and 60.9% during IA clamping, respectively; 64.0% and… More >
Graphic Abstract
Open Access
CASE REPORT
Congenital Heart Disease, Vol.18, No.6, pp. 649-656, 2023, DOI:10.32604/chd.2023.027987
Abstract Background: Children with congenital heart disease (CHD), even after surgical approaches, and especially those who undergo staged procedures in the first months of life, remain vulnerable to readmissions and complications, requiring very close monitoring and differentiated intervention strategies. Methods: Descriptive and exploratory study, of the experience report type, which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases (AAR) at the Instituto do Coração (InCor). Results: Report of the path taken to structure the AAR, demonstrating the organization, interface with the multidisciplinary team, admission and discharge criteria, training, and patient profile. In these five years… More >
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 657-670, 2023, DOI:10.32604/chd.2023.044179
Abstract Background: Congenital heart disease (CHD) is a chronic medical condition often diagnosed at birth and requires surgical intervention, multiple hospitalizations, and lifelong care. This can put significant stress on the family, leading to altered maternal mental health, bonding and attachment issues, and the potential for child abuse. The purpose of this study is to explore the characteristics of a sample of young children with CHD who experienced hospitalization with concurrent concern for child abuse in a free-standing pediatric tertiary care hospital. Methods: Electronic medical records were reviewed for children aged 0–5 years old who were hospitalized with concern for child… More >
Open Access
CASE REPORT
Congenital Heart Disease, Vol.18, No.6, pp. 671-678, 2023, DOI:10.32604/chd.2023.044746
Abstract Tetralogy of Fallot (TOF) with total anomalous pulmonary vein connections (TAPVC) is a rare type of complex congenital heart disease among all TOF cases. Co-presentation of major aortopulmonary collateral arteries (MAPCAs) compensates for the lack of central pulmonary blood flow and decreases the severity of right-to-left shunting in TOF. We present a case of a 2-year-old child with complex diagnoses of TOF, TAPVC, a large secundum atrial septal defect (ASD), and intraoperatively identified MAPCAs. She underwent surgery to repair the TAPVC, valve-sparing reconstruction of the right ventricular outflow tract, interventricular defect closure, and the creation of patent foramen ovale (PFO).… More >
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 679-691, 2023, DOI:10.32604/chd.2023.020028
Abstract Background: Closure of an atrial septal defect (ASD) reduces right-side heart volumes by abolishing shunting with simultaneous improvement of the left ventricle (LV) filling and functions due to ventricular interdependence, thereby improving symptoms. Furthermore, studies conducted on atrial volume changes after ASD closure are limited. Cardiac magnetic resonance (CMR) is considered as the gold standard method for measuring cardiac volume and mass. Objective: We aimed to study the effect of transcatheter and surgical closure of secundum ASD on cardiac volumes and systolic functions as well as the fate of tricuspid regurgitation (TR), using CMR analysis. Methods: We prospectively enrolled 30… More >
Open Access
ARTICLE
Congenital Heart Disease, Vol.18, No.6, pp. 693-701, 2023, DOI:10.32604/chd.2024.048081
Abstract CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression. The development of human diseases involves important regulatory roles of RNAs, and expression profiling data can reflect the underlying etiology of inherited diseases. Hence, collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases. CHDTEPDB stores the expression profiles of over 200 sets of 7… More >