@Article{JPM.2021.38.3-4.10,
AUTHOR = {S. DEIVANAYAKI, P. JAYAMURUGAN, S. ASHOKAN, V. GOPALA KRISHNAN, B. YOGESWARI},
TITLE = {Growth of Non-enzymatic Cholesterol Biosensor using TiO<sub>2</sub>  Decorated Graphene Oxide with Bare GCE and PPy-GCE},
JOURNAL = {Journal of Polymer Materials},
VOLUME = {38},
YEAR = {2021},
NUMBER = {3-4},
PAGES = {295--307},
URL = {http://www.techscience.com/jpm/v38n3-4/56033},
ISSN = {0976-3449},
ABSTRACT = {The cholesterol level determination is a significant clinical diagnostic solution for heart and,
thrombosis problems. In this work, we examined a novel non-enzymatic cholesterol biosensor
using cholesterol oxidase (ChOx) enzyme immobilized on TiO<sub>2</sub>
 nanoparticles influenced by
reduced graphene oxide (rGO) - polypyrrole (PPy) (rGO-TiO<sub>2</sub>
/PPy-GCE) nanocomposite was
developed on a glassy carbon electrode (GCE) and the higher sensing response with lower
detection limits were observed. The electrochemical properties of GCE modified PPy (PPy-GCE) were studied using CV (Cyclic Voltammetry) and DPV (Differential Pulse Voltammetry).
The reported sensor exhibited piecewise linearity in the range of 0.1 µM to 1 µM and 1 µM to 600
µM with the sensing response of 61.665 and 0.1466 (2μA μM×cm) respectively. The detection
limits of the sensor were found to be 32 nm. The results were repeatable and reproducible and
this sensor can be applied to determine the cholesterol at real sample with satisfactory results.},
DOI = {10.32381/JPM.2021.38.3-4.10}
}