@Article{JPM.2023.40.3-4.10,
AUTHOR = {SOBHA KOTA, RATNAKUMARI ANANTHA, VAYUNANDANA RAO GOVADA, PRADEEP DUMPALA},
TITLE = {Chitosan/PVA Films and Silver Nanoparticle Impregnated Nanofibrous Dressings for Evaluation of their Wound Healing Efficacy in Wistar Albino Rat Model},
JOURNAL = {Journal of Polymer Materials},
VOLUME = {40},
YEAR = {2023},
NUMBER = {3-4},
PAGES = {285--303},
URL = {http://www.techscience.com/jpm/v40n3-4/56011},
ISSN = {0976-3449},
ABSTRACT = {The exoskeleton of marine shrimp contains a natural, biocompatible polymer chitin, which is
dumped as a waste. The study proposes the sustainable single-pot-extraction of chitosan from
the waste and its use in the fabrication of wound-dressings, and thus leverage its piezoelectric,
antioxidant, hypoglycaemic and medicinal properties in wound-healing. The Fourier transform
infrared spectrum revealed that marine chitosan contains functional groups with N-O, O-H, and
CO stretching. Scanning electron micrographs demonstrated the spherical and mesoporous
structures of the extracted chitosan. X-ray diffraction analysis showed a semi-crystalline phase
of chitosan particles with a mean size of 28.9 nm. The film prepared with marine shrimp chitosanpolyvinyl alcohol (PVA) composite, and used as a wound dressing exhibited significant wound
healing properties with a regeneration efficiency of 78% in 8 days in Wistar albino rats. The
wound healing efficiency was enhanced by the addition of cost effective, non-toxic/environmentally
friendly silver nanoparticles (AgNPs) synthesized from Rumex acetosa (sorrel) plant extracts
and electrospinning of the nanofibrous composites of chitosan/PVA/AgNPs with high
antibacterial, antioxidant and wound healing capacity of 96% in 8 days. Thus, the current study
supports the use of a natural piezoelectric chitosan polymer as a wound dressing material,
either in film or nanofiber, for normal as well as diabetic wounds.},
DOI = {10.32381/JPM.2023.40.3-4.10}
}