@Article{jrm.2025.02025-0180,
AUTHOR = {Tamer Y. A. Fahmy, Samir Kamel, Ahmed M. Khalil},
TITLE = {Smart Nano-Cellulosic-Based Materials as Antiviral Agents: A Brief Insight into Scientific Advances and Functionalization Strategies},
JOURNAL = {Journal of Renewable Materials},
VOLUME = {},
YEAR = {},
NUMBER = {},
PAGES = {{pages}},
URL = {http://www.techscience.com/jrm/online/detail/25163},
ISSN = {2164-6341},
ABSTRACT = {The growing threat of viral pandemics necessitates innovative antiviral strategies that are effective, sustainable, and scalable. This review highlights nanocellulose as a renewable, biocompatible nanomaterial and a promising multifunctional antiviral platform. We examine cellulose nanocrystals, nanofibrils, and bacterial nanocellulose, emphasizing their synergistic antiviral mechanisms, including nanoscale viral entrapment and surface-mediated inactivation via sulfation, cationic groups, and metal nanoparticles. Key advances include photothermally active nanocellulose-graphene composites for on-demand viral deactivation, sulfated nanocellulose mimicking heparin’s virus-trapping properties, and engineered biopolymer hybrids for targeted drug delivery and mucosal immunity. Translational applications span antiviral coatings, self-sterilizing filters, and regenerative wound dressings. The review also addresses scalability and regulatory challenges, integrating computational modeling and structure-activity relationships to guide real-world implementation. Nanocellulose-based technologies offer a transformative approach to antiviral defense, merging adaptability, sustainability, and multifunctionality to meet the demands of pandemic preparedness and redefine the future of biomedical materials.},
DOI = {10.32604/jrm.2025.02025-0180}
}