@Article{jrm.2026.02025-0198,
AUTHOR = {Huan Long, Emmanuel Abu-Danso, Mônica Rufino Senra, Leonid Ionov, Jussi V. K. Kukkonen, Holger Ruckdäschel},
TITLE = {Renewable Polymeric Tissue Scaffolding: Trends in Structural Development},
JOURNAL = {Journal of Renewable Materials},
VOLUME = {},
YEAR = {},
NUMBER = {},
PAGES = {{pages}},
URL = {http://www.techscience.com/jrm/online/detail/27537},
ISSN = {2164-6341},
ABSTRACT = {Polymeric scaffolds are now widely used in biomedical engineering to reconstruct tissues as well as other corrective medical applications. They are designed to promote the proliferation of the host cell and provide load-bearing capabilities. Through tailored fabrication methods and material compatibility, polymeric scaffolds can be applied either temporarily or permanently, and successful applications have resulted in commercialized products. Currently, there is a high interest in tissue scaffolds that combine both effective mechanical performance with efficient surface response functionalities. In this work, we performed an in-depth comparative analysis of tissue scaffolds made from renewable parent materials, their production routes, and performance at laboratory scale, patents, and commercialized products. From the literature reviewed, natural polymer-based scaffolds demonstrate superior vascularization whereas the partially biosourced constructs exhibit mechanical advantage. These suggest that combining optimized features from both material classes could yield scaffolds with enhanced stress-strain properties, high vascularization and porosity. To tailor scaffold performance, we found that the flexibility of 3-Dimensional (3D) printing particularly precision laser writing technology, offers a more efficient fabrication approach as it enables the production of hierarchical scaffold capable of performing different functions across different size scales. We found a gap in (i) the knowledge of leveraging the similarities between plant and animal cellularized systems, (ii) the use of self-healing and shape-memory smart materials, and (iii) <i>ex vivo</i> culturing in bioreactor systems and subsequent seeding. To date, most tissue scaffold engineering research work remains at the laboratory scale, therefore, more effort is needed in upscaling, as well as in research and development. Diverse methodologies and materials still need to be explored for fit-for-purpose tissue scaffolds that can meet future needs.},
DOI = {10.32604/jrm.2026.02025-0198}
}