TY  - EJOU
AU  - Abdalla, Soliman 
AU  - Kandil, Shiref 

TI  - Construction of Customized Bio Incubator and Designing of Tailored Scaffolds for Bone Tissue Engineering from Laboratory Scale Up to Clinical Scale
T2  - Journal of Renewable Materials

PY  - 2022
VL  - 10
IS  - 11
SN  - 2164-6341

AB  - In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get better products. The present study concludes that some techniques with cultured cell in segmental bone grafts in the laboratory can be transferred and clinically used.
KW  - Repairing segmental bone; customized scaffolds; stem cells; designing bio incubator; bone engineering

DO  - 10.32604/jrm.2022.022334