@Article{jrm.2023.022535,
AUTHOR = {Jiayu Chang, Qingying Ding, Chong Zhong, Yao Long, Zhuanquan Xiao, Hai Luo, Yuling Yang, Zongde Wang, Shengliang Liao, Jinzhu Chen, Shangxing Chen, Ji Zhang},
TITLE = {Synthesis and Antioxidant Activity of (E) ω-Formylcamphene-Based Thiazole Hydrazone Derivatives},
JOURNAL = {Journal of Renewable Materials},
VOLUME = {11},
YEAR = {2023},
NUMBER = {1},
PAGES = {379--391},
URL = {http://www.techscience.com/jrm/v11n1/49255},
ISSN = {2164-6341},
ABSTRACT = {(E) ω-formylcamphene was synthesized from α-pinene, the main component of turpentine, and then reacted with thiosemicarbazide to obtain (E) ω-formylcamphene thiosemicarbazide <b>3</b>, which was reacted with 14 α-bromoacetophenone compounds to obtain 14 (E) ω-formylcamphene thiazole hydrazone compounds <b>5a</b>–<b>5n</b>; the yields were all above 80%. The structures of the target compounds were characterized by IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and HR-MS analyses. Then, 500, 250, 125, 62.5, and 31.25 mg/L drug solutions were prepared. Free radical scavenging experiments of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2-bis (3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt (ABTS) were carried out with Trolox and L-ascorbic acid as the control samples. The scavenging rates of 14 compounds for DPPH and ABTS free radicals were obtained; the IC<sub>50</sub> values of scavenging free radicals were fitted using SPSS software. The results show that 14 (E) ω-formylcamphene-based thiazole hydrazone compounds exhibited good scavenging effects on the two free radicals, especially when the concentration of the drug solution was 125 and 62.5 mg/L; most compounds exceeded the scavenging efficiency of Trolox and L-ascorbic acid.},
DOI = {10.32604/jrm.2023.022535}
}