@Article{jrm.2023.026333,
AUTHOR = {Jiulong Wang, Yanqing Gao, Xiaoping Rao, Zongde Wang, Shibin Shang, Zhanqian Song, Hongyan Si, Shengliang Liao},
TITLE = {Preparation of Amide-Containing Insecticidal Derivatives from the Renewable Natural Product <i>β</i>-Pinene},
JOURNAL = {Journal of Renewable Materials},
VOLUME = {11},
YEAR = {2023},
NUMBER = {5},
PAGES = {2367--2379},
URL = {http://www.techscience.com/jrm/v11n5/51715},
ISSN = {2164-6341},
ABSTRACT = {The preparation of bioactive derivatives from the renewable natural product pinene is a hot research topic in the deep processing and utilization of pinene. In this study, <i>β</i>-pinene was used to develop novel molecules as a promising new precursor of insecticide. A series of amide-containing derivatives of <i>β</i>-pinene were synthesized and characterized. The insecticidal activities of these derivatives against <i>Mythimna separate</i> and <i>Semiaphis heraclei</i> were tested. The structure characterization results showed that the characterization data of amide-containing derivatives were in full agreement with their proposed structures. The insecticidal activities evaluation results indicated that amide-containing derivatives exhibited weak insecticidal activity against <i>Mythimna separate</i>, but exhibited moderate to good insecticidal activity against <i>Semiaphis heraclei</i>. After testing for 72 h, the corrected mortality against <i>Semiaphis heraclei</i> of compounds 5c, 5e, 5f, 5 h, 5j, and 5 m was 100% at 1000 mg/L. The structure-activity relationship analysis results showed that the introduction of an amide group into the structure of derivatives improved their insecticidal activity against <i>Semiaphis heraclei</i>. Meanwhile, the amide-containing derivatives containing the F and NO<sub>2</sub> substituted benzene ring might improve their insecticidal activity against <i>Semiaphis heraclei</i>. This study will be helpful for the high value-added utilization of the natural renewable resource <i>β</i>-pinene and the development of novel insecticides.},
DOI = {10.32604/jrm.2023.026333}
}