TY  - EJOU
AU  - Li, Yiwen 
AU  - Si, Hongyan 
AU  - Wang, Peng 
AU  - Luo, Hai 
AU  - Shen, Minggui 
AU  - Rao, Xiaoping 
AU  - Song, Zhanqian 
AU  - Shang, Shibin 
AU  - Wang, Zongde 
AU  - Liao, Shengliang 

TI  - High-Value-Added Utilization of Turpentine: Screening of Anti-Influenza Virus Agents from <i>β</i>-Pinene Derivatives
T2  - Journal of Renewable Materials

PY  - 2024
VL  - 12
IS  - 1
SN  - 2164-6341

AB  - Turpentine is a renewable and resourceful forest product. The deep processing and utilization of turpentine, particularly its primary component <i>β</i>-pinene, has garnered widespread attention. This study aimed to synthesize 40 derivatives of <i>β</i>-pinene, including nopinone, 3-cyanopyridines of nopinone, myrtanyl acid, myrtanyl acylthioureas, and myrtanyl amides. We assessed the antiviral activities of these <i>β</i>-pinene derivatives against influenza virus A/Puerto Rico/8/34 (H1N1) using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. The <i>β</i>-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus. The results showed that only compound 10o exhibited a preventive effect against the H1N1 virus with a half-maximal inhibitory concentration (IC<sub>50</sub>) value of 47.6 μmol/L. Among the compounds, 4e, 4i, and 4l demonstrated therapeutic effects against cellular infection, with compound 4e displaying the most potent therapeutic effect (IC<sub>50</sub> = 17.5 μmol/L), comparable to the positive control ribavirin. These findings indicated that certain <i>β</i>-pinene derivatives exhibited <i>in vitro</i> antiviral activity against the H1N1 influenza A virus, warranting further investigation as potential anti-influenza agents.
KW  - Antiviral activity; <i>β</i>-pinene; derivative; 3-cyanopyridine; influenza virus

DO  - 10.32604/jrm.2023.031089