@Article{jrm.2019.07757,
AUTHOR = {Xiaoliang Zhao, Yuting Wang, Xiuying Pu, Jianzhong Ma, Feifan Leng, Yonggang Wang, Yanling Wang, Shuhong Yang, Fen Ran, Weijie Zhang},
TITLE = {Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres},
JOURNAL = {Journal of Renewable Materials},
VOLUME = {7},
YEAR = {2019},
NUMBER = {12},
PAGES = {1321--1332},
URL = {http://www.techscience.com/jrm/v7n12/38046},
ISSN = {2164-6341},
ABSTRACT = {A series of the Guiqi polysaccharides/chitosan/alginate composite
hydrogel microspheres (GPcM) with different particle sizes were prepared with
Guiqi polysaccharides (GP), chitosan (CS) and sodium alginate (Alg). The
optimum preparation process was also determined by single factor and
orthogonal experiment analysis. The GPcM were characterized by fourier
transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM),
drug loading efficiency test (LE), encapsulation efficiency test (EE) and in vitro
release study. The results showed that the Guiqi polysaccharides chitosan
hydrogel (GPCH) and sodium alginate hydrogel (SAH) formed a crossover
system in GPcM. The GPcM have a uniform particle size ranging from 395.1μm
to 841.5μm. The drug loading efficiency and encapsulation efficiency of the
GPcM were 56.3% and 72.6%, respectively. The bovine serum albumin (BSA)
loaded in the GPcM released slowly within 180 h. The results suggested that the
GPcM may have potential application value in drug sustained and controlled
release system.},
DOI = {10.32604/jrm.2019.07757}
}