@Article{jrm.2020.09206,
AUTHOR = {Mariia Stepanova, Ilia Averianov, Olga Solomakha, Natalia Zabolotnykh, Iosif Gofman, Mikhail Serdobintsev, Tatiana Vinogradova, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh},
TITLE = {Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals},
JOURNAL = {Journal of Renewable Materials},
VOLUME = {8},
YEAR = {2020},
NUMBER = {4},
PAGES = {383--395},
URL = {http://www.techscience.com/jrm/v8n4/38711},
ISSN = {2164-6341},
ABSTRACT = {The biocomposite films were prepared from poly(L-lactic acid) and cellulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulose
nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties, cellulose was functionalized with poly(glutamic acid). The
modified cellulose nanocrystals were better distributed and less aggregated within
the matrix, which was testified by scanning electron, optical and polarized light
microscopy. According to mechanical tests, composites filled with nanocrystals
modified with PGlu demonstrated higher values of Young’s modulus, elongation
at break and tensile strength. Incubation of composite materials in model buffer
solutions for 30 weeks followed with staining of Ca<sup>2+</sup> deposits with Alizarin
Red S assay testified better mineralization of materials containing PGlu-modified
cellulose nanocrystals as filler. As the result of <i>in vivo</i> experiment, the developed
composite materials showed less level of inflammation in comparison with pure
polymer matrix and composites filled with non-functionalized cellulose
nanocrystals.},
DOI = {10.32604/jrm.2020.09206}
}