TY  - EJOU
AU  - Modarres, Hassan P.  
AU  - Mofrad, Mohammad R. K.  

TI  - Filamin: A Structural and Functional Biomolecule with Important Roles in Cell Biology, Signaling and Mechanics
T2  - Molecular \& Cellular Biomechanics

PY  - 2014
VL  - 11
IS  - 1
SN  - 1556-5300

AB  - Focal adhesions are the immediate sites of the cell’s adhesive interaction with the extracellular matrix and as such play a key role in mechanosensing and mechanotransduction at the edge of the cell interface with its surrounding microenvironment. A multitude of proteins orchestrate this mechanochemical communication process between the cell and its outside world. Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light on the role of filamin’s protein-protein interaction network in cell mechanobiology.
KW  - 

DO  - 10.3970/mcb.2014.011.039