@Article{mcb.2017.014.035,
AUTHOR = {Kun Fan, Xiaofu Qiu, Yu Fu, Kangjian Lin, Huanhui Li, Guosheng Yang},
TITLE = {Amentoflavone Suppresses Cell Growth and Invasion in Renal Carcinoma Cells by Activating PPARγ},
JOURNAL = {Molecular \& Cellular Biomechanics},
VOLUME = {14},
YEAR = {2017},
NUMBER = {1},
PAGES = {33--45},
URL = {http://www.techscience.com/mcb/v14n1/28597},
ISSN = {1556-5300},
ABSTRACT = {This study intends to investigate the role of amentoflavone(AF) in human clear-cell renal cell carcinoma (ccRCC) and to elucidate underlying molecular mechanisms. Materials and Methods: Human RCC cell lines Caki-1 and 786-O were used in this study. Cell proliferation, apoptosis, cell cycle distribution and invasion assays were conducted to analyze the effect of AF against ccRCC <i>in vitro</i>. Xenograft model and pulmonary metastasis animal model were established to evaluate the vivo therapeutic efficacy and against pulmonary metastasis ability of AF, respectively. Results: Our findings revealed that AF selectively suppressed tumor cell proliferation in a dose- and time-dependent manner. Treatment with AF significantly elevated the percent proportion of apoptotic cells and blocked cell cycle progression. Moreover, AF inhibited cell invasion in a dose-dependent fashion. Our findings revealed AF activated PPARγ, which accounts for its anti-tumor activities. Conclusions: Our findings suggest AF suppresses tumor growth and metastasis by activating PPARγ.},
DOI = {10.3970/mcb.2017.014.035}
}