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ABSTRACT

Fast Force Loading Disrupts Molecular Bond Stability in Human and Mouse Cell Adhesions

Yunfeng Chen1,2,3,†,*, Jiexi Liao4,†, Zhou Yuan1, Kaitao Li4, Baoyu Liu4, Lining Arnold Ju4,5,6, Cheng Zhu1,2,4,5,*

1 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
2 Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;
3 Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA;
4 Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;
5 Heart Research Institute, The University of Sydney, Camperdown, NSW 2006, Australia.
6 Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.
† These authors contribute equally.
* Corresponding Authors: Yunfeng Chen. Email: cheny@scripps.edu; Cheng Zhu. Email: cheng.zhu@bme.gatech.edu.

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