@Article{mcb.2020.08750,
AUTHOR = {Shicheng He, Juhui Qiu, Wanling Liu, Tieying Yin, Dechuan Zhang, Donghua Liao, Haijun Zhang, Yuxia Yin, Guixue Wang},
TITLE = {A Patient-Specific Computational Fluid Dynamic Model of Middle Cerebral Artery Aneurysm Before and One Year After Surgery},
JOURNAL = {Molecular \& Cellular Biomechanics},
VOLUME = {17},
YEAR = {2020},
NUMBER = {2},
PAGES = {63--74},
URL = {http://www.techscience.com/mcb/v17n2/38478},
ISSN = {1556-5300},
ABSTRACT = {Computational fluid dynamics (CFD) has been widely used for studying intracranial aneurysm hemodynamics, while its use for guiding clinical strategy is still in development. In this study, CFD simulations helped inform
treatment decision for a middle cerebral artery (MCA) aneurysm case was investigated. A patient with a 10.4 × 9.8 mm aneurysm attached with a small aneurysm
at the edge of the trifurcation in the left MCA was included in this study. For
removing the MCA aneurysm, two scenarios were considered: Plan-A involved
clipping the small aneurysm and Plan-B involved clipping the whole aneurysm.
A suitable treatment plan was decided by comparing the clinical measurements
and CFD analysis between these two plans. One-year after the surgery, the
CFD analysis was conducted again on the post-operative aneurysm model to verify the selected surgical plan in terms of morphometric and hemodynamic properties changes in the aneurysm. Based on the CFD simulation and clinical
experience, surgical Plan-A was adopted. One-year after the surgery, both the
hemodynamic and morphological properties improved in the post-operative
aneurysm model, indicating the recovery of the patient. The patient-specific
aneurysm CFD analysis can help to determine a better surgical plan for patients
with special cerebral aneurysms. This study showed how CFD analysis can be
used to aid clinical diagnosis and treatment.},
DOI = {10.32604/mcb.2020.08750}
}