@Article{mcb.2022.018345,
AUTHOR = {Abdossaleh Zar, Fatemeh Ahmadi, Forouzan Karimi, Mozhgan Ahmadi, Roger Ramsbottom},
TITLE = {Effect of Resistance Training and <i>Spirulina platensis</i> on Expression of IL-6, Gp130 Cytokines, JAK-STAT Signaling in Male Rats Skeletal Muscle},
JOURNAL = {Molecular \& Cellular Biomechanics},
VOLUME = {19},
YEAR = {2022},
NUMBER = {1},
PAGES = {51--59},
URL = {http://www.techscience.com/mcb/v19n1/46230},
ISSN = {1556-5300},
ABSTRACT = {The effect of resistance training and a herbal supplement on muscular signaling pathways are limited. We investigated the expression of IL-6, Gp130, JAK and STAT after resistance training, and <i>Spirulina platensis</i> supplementation in animal muscle. Thirty-two male Sprague Dawley rats (weight: 290 ± 20 g, and 9 weeks of age) were divided into four groups: control (CO; n = 8), <i>Spirulina platensis</i> supplementation (SP; n = 8), resistance exercise (RE; n = 8), and <i>Spirulina platensis</i> + resistance exercise (SP + RE; n = 8). The resistance exercise group trained five sessions each week for eight weeks. Spirulina 200 mg kg<sup>−1</sup> d<sup>−1</sup> was used in the SP and SP + RE groups. Gene expression was measured by real-time PCR following the last training session. One-way ANOVA test with Tukey’s post-hoc test were used for analysis of data (SPSS, version, 21). Data analysis revealed that the expression of IL-6 (<i>P</i> = 0.001), Gp130 (<i>P</i> = 0.001), JAK (<i>P</i> = 0.0001) and STAT (<i>P</i> = 0.004) increased significantly in the RE group. The expression of IL-6 (<i>P</i> = 0.018), JAK (<i>P</i> = 0.001) and STAT (<i>P</i> = 0.001) in SP + RE group also increased significantly (<i>P</i> ≤ 0.05). SP showed a significant increase in Gp130 (<i>P</i> = 0.001) and STAT (<i>P</i> = 0.001). Supplementation by <i>Spirulina platensis</i> may enhance muscle accretion during resistance training.},
DOI = {10.32604/mcb.2022.018345}
}