@Article{mcb.2004.001.211, AUTHOR = {Min Yue, Jeanne C. Stachowiak,2,2, Arunava Majumdar,3,3}, TITLE = {Cantilever Arrays for Multiplexed Mechanical Analysis of Biomolecular Reactions}, JOURNAL = {Molecular \& Cellular Biomechanics}, VOLUME = {1}, YEAR = {2004}, NUMBER = {3}, PAGES = {211--220}, URL = {http://www.techscience.com/mcb/v1n3/33592}, ISSN = {1556-5300}, ABSTRACT = {Microchips;ontaining arrays of cantilever beams have been used to mechanically detect and quantitatively analyze multiple reactions of DNA hybridization and antigen-antibody binding simultaneously. The reaction-induced deflection of a cantilever beam reflects the interplay between strain energy increase of the beam and the free energy reduction of a reaction, providing an ideal tool for investigating the connection between mechanics and chemistry of biomolecular reactions. Since free energy reduction is common for all reactions, the cantilever array forms a universal platform for label-free detection of various specific biomolecular reactions. A few such reactions and their implications in biology and biotechnology are discussed.}, DOI = {10.3970/mcb.2004.001.211} }