@Article{mcb.2004.001.211,
AUTHOR = {Min  Yue, Jeanne C.  Stachowiak, Arunava  Majumdar},
TITLE = {Cantilever Arrays for Multiplexed Mechanical Analysis of Biomolecular Reactions},
JOURNAL = {Molecular \& Cellular Biomechanics},
VOLUME = {1},
YEAR = {2004},
NUMBER = {3},
PAGES = {211--220},
URL = {http://www.techscience.com/mcb/v1n3/33592},
ISSN = {1556-5300},
ABSTRACT = {Microchips;ontaining arrays of cantilever beams have been used to mechanically detect and quantitatively analyze multiple reactions of DNA hybridization and antigen-antibody binding simultaneously. The reaction-induced deflection of a cantilever beam reflects the interplay between strain energy increase of the beam and the free energy reduction of a reaction, providing an ideal tool for investigating the connection between mechanics and chemistry of biomolecular reactions. Since free energy reduction is common for all reactions, the cantilever array forms a universal platform for label-free detection of various specific biomolecular reactions. A few such reactions and their implications in biology and biotechnology are discussed.},
DOI = {10.3970/mcb.2004.001.211}
}